Can Dogs Take Trazodone and Benadryl Together?

Can Dogs Take Trazodone and Benadryl Together

Let’s be honest, that little ball of fur is more than just a pet: they’re part of the family.


And when they get sick or hurt, you want to make sure you’re doing everything you can to help them feel better.


That includes making sure any medications you give them are safe and effective for treating your pooch’s specific ailments.


One question we often hear from dog owners is whether it’s okay to give their pups both trazodone and Benadryl as anxiety relief medication.


It’s an important question, too: these two drugs are incredibly common for addressing anxiety issues in dogs because they are both safe and effective on their own.


But can dogs take trazodone and Benadryl together?


Read on for the answer!


Can you give dog trazodone and Benadryl together?

Trazodone and Benadryl for dogs


The answer is yes. Trazodone and Benadryl can be given together to your dog, but only under the supervision of a veterinarian.


Trazodone is an antidepressant that is used in humans to treat anxiety, depression, and insomnia while Benadryl treats allergies and itching caused by pets or food items.


This means that if your dog has been diagnosed with any of these conditions then he may receive either one or both drugs depending on his condition.


How are trazodone and Benadryl used together?

You may be concerned about using trazodone with Benadryl because you don’t know how they work together, or if they are even safe to use together.


Trazodone (Desyrel®) is an antidepressant that works by altering levels of neurotransmitters in the brain and Benadryl (Diphenhydramine) is an antihistamine that treats allergies and causes drowsiness.


When trazodone and Benadryl are used together, they are typically used to treat insomnia or anxiety.


Trazodone has been shown to have a sedative effect on people who take it, which can cause them to fall asleep more easily at night when they’re taking this medication along with another one like Diphenhydramine (Benadryl®).


This combination can also help reduce some of the side effects associated with taking antidepressants like Trazodone such as nausea and vomiting caused by motion sickness or migraine headaches caused by chemotherapy treatments due to nausea/vomiting since these medications act as antiemetics by blocking certain receptors that control vomiting reflexes.



Learn More:

Can Dogs Have Canned Chicken



Are there any side effects of using trazodone and Benadryl together?

The most common side effects of using trazodone and Benadryl together include:

  • Dizziness
  • Trouble sleeping
  • Nausea, stomach pain, or vomiting

These side effects are more likely to occur when you first start taking these medications.


If you experience any of these symptoms, talk with your doctor about whether it’s time for a dosage change.



Overall, trazodone and Benadryl are effective in treating anxiety and other conditions in dogs.


However, you should use them only when prescribed by a vet as using them together or in excess can lead to serious side effects.


Always follow your vet’s advice on the right dosages for your dog to avoid any complications.


See Also


A pet owner who loves to share useful facts and information about a variety of animals.